Dr. Thomas Abraham

Dr. Thomas Abraham is a microscopy expert located at the James Hogg Research Centre, whose current research centers on the development of high resolution biomedical imaging based on the modern optical principles, particularly harmonic generation and multiphoton microscopy methods applied to heart and lung research. Thomas Abraham holds a Ph. D. degree in Chemical Engineering from the Laval University (Canada), and has been a post doctoral trainee in Biophysics/ Structural Biology at various institutions in Canada, Japan and Sweden. Thomas is a SPIE member and has published extensively in various optical and biophysical methods addressing important biological problems. [http://www.ncbi.nlm.nih.gov/pubmed?term=Abraham%20T%20and%20Canada]. 

Contact: Thomas.Abraham@hli.ubc.ca


Keddie Brown

Keddie Brown is a research engineer with a background in physics, and electrical and mechanical engineering.  He manages the Technology Development Core at the Institute for Heart + Lung Health where he assists researchers in designing and constructing apparatus.  Keddie received his degree in Applied Sciences at UBC in 2006 through the Engineering Physics program specializing in Electrical Engineering. He also has two diplomas in Mechanical Technology from BCIT that he completed in 1996 and 1997 and several years of work experience in the life sciences field.

Contact: Keddie.Brown@hli.ubc.ca


Dr. Del Dorcheid

Dr. Dorscheid is a member of the Divisions of Critical Care Medicine and Respirology at St. Paul 's Hospital, one of the University of British Columbia hospitals.  Dr. Dorscheid attends in the medical intensive care unit at St. Paul 's and is a researcher in the James Hogg Research Centre. As a physician-scientist, he leads an active research group investigating the role of the airway epithelium in the genesis of inflammatory airways diseases. The research program studies the role for inappropriate injury-repair cycles in the development of both chronic diseases such as asthma and acute illnesses like ALI/ARDS.  Dr Dorscheid is the principal applicant and project leader for BRONCH.

Contact: Del.Dorscheid@hli.ubc.ca




Andrew J. Halayko, PhD

Dr. Halayko is a Professor in the Departments of Physiology, Internal Medicine, and Pediatrics & Child Health at the University of Manitoba, and holds a Tier II Canada Research Chair in Airway Cell and Molecular Biology.  He is Leader of the Biology of Breathing Group in the Manitoba Institute of Child Health, Director of the Asthma/COPD Centre and Fellowship Research Director in the Section of Respiratory Diseases.

Dr. Halayko’s research has been instrumental in building current concepts of phenotype plasticity of airway smooth muscle and its role in asthma pathogenesis.  He directs a translational research program to investigate mechanisms orchestrating airway inflammation, remodeling, and hyperresponsiveness –current interests focus on: (1) caveolins in lung mesenchymal cell function, (2) the potential for inhibitors associated with the mevalonate cascade to treat obstructive airway disease, (3) the effects of statins on viral infection of human airway epithelial cells, (4) S100 proteins in allergic airway inflammation and steroid-refractory asthma, and (5) developing bio-engineered airway and blood vessels populated with human somatic and /or stems cells to facilitate translation of discovery research evidence to clinical testing.

In his career Dr. Halayko has over 120 peer-reviewed articles.  He holds funding from the Canadian Institutes of Health Research, industry partners, and he is a Executive Mentor for the CIHR Strategic Training Program: IMPACT (Cardio-pulmonary research and disease).  He has been principal applicant or co-applicant on 5 major Canada Foundation for Innovation infrastructure awards, and is currently co-leading development of two core research platforms at U of Manitoba: (1) in vivo imaging for small animal models of human disease, and (2) a Bio-Engineering Research and Development Unit.

In addition to academic and research duties, Halayko is an active member of the American Thoracic Society having served on a number of committees, and serving as elected Chair of the Respiratory Structure and Function Assembly and ATS Board of Directors member.  He is also currently a member of the Board of the Canadian Thoracic Society (CTS), being Chair of both the CTS Research Committee, and CTS Research Steering Committee for Development of a National Respiratory Research Strategy.  He is also a member of the Board of Directors (Research Committee Chair) of the Manitoba Lung Association.

Contact: ahalayk@cc.umanitoba.ca

sam Sam J Wadsworth, PhD

Dr Sam Wadsworth is the BRONCH project coordinator.  He studied his PhD in respiratory cell biology at the University of Nottingham, UK, and is currently a post-doctoral research fellow at the James Hogg Research Centre within the Institute for Heart + Lung Health at UBC, Vancouver. His work to date has focused on the airway epithelium and its varied roles in health and in chronic diseases such as asthma.

Dr Wadsworth has published several papers defining how the epithelium of the airway interacts with its environment, and how inhaled drugs such as corticosteroids, and inflammatory signals modulate these interactions.  In addition to BRONCH, current research projects include; 1) finding novel regulatory mechanisms of airway epithelial proteases, 2) investigating the role of sex hormones on the epithelium in chronic disease, 3) developing improved in vitro models of the airway epithelium.  As a dedicated in vitro cell biologist, much of Dr Wadsworth’s research has revolved around in vitro modeling of the human airway, his previous work has already provided much of the impetus for the BRONCH project.

“I’m very excited to be part of the BRONCH project. It represents a huge step-forward in developing a physiologically-relevant human airway model with real-life applicability in drug testing, developmental biology, and disease research.”

Contact: Samuel.Wadsworth@hli.ubc.ca


Malcolm Xing

Dr. Malcolm (Mengqiu) Xing is an assistant Professor in the Department of Mechanical and Manufacturing Engineering, Faculty of Engineering and the Department of Biochemistry & Biomedical Genetics, Faculty of Medicine at the University of Manitoba.  He obtained his Ph.D from the University of California, Davis and was trained as fellow at the Harvard Medical School, Brigham and Women’s Hospital before moving to Winnipeg in October, 2009.

Dr. Xing’s research focuses on the development of nanotechnology and biomaterials for tissue engineering and nanomedicine.  His current research projects include (1) the establishment of 3-D nanofibrous scaffolds and stem cells for the regeneration of vascular grafts, bone and skin, (2) the design of injectable hydrogel for cardiovascular and orthopaedic applications, and (3) the development of nano-vectors to fight cancer and to delivery therapeutic genes and siRNA.

Dr. Xing has over 20 publications in peer review journals including Biomacromolecules, Nanomedicine, Polymer, Lab on Chip, Langmuir, Journal of Biomechanical Engineering et al.  He current holds 8 grants to develop tissue engineering program at the University of Manitoba. He was awarded Dr. Moore house Fellowship Award by Diabetes Foundation of Manitoba for his research on novel nanotechnology and bio-composite on skin ulcer in 2011. His research has been reported by CTV-news.

In addition to his academics, he is also active members of Biomaterials Society as an officer in Tissue Engineering Group and Termis (Tissue Engineering and Regenerative Medicine Society).

Contact: xing@cc.uanitoba.ca

Link: http://umanitoba.ca/faculties/engineering/departments/mechanical/staff/profiles/xing.html


Min Hyung Ryu

Min Hyung Ryu is a young scientist who graduated from Queen's University, Kingston Ontario with a B.Sc. degree in Life Sciences (Hons). He is currently pursuing his graduate degree at the University of Manitoba under Dr. Halayko's supervision, where he is investigating the effect of persistent exposure to environmental organic pollutants on the pathogenesis of asthma in vivo. He is interested in studying the same environmental stimuli in vitro using the bioengineered airway the BRONCH team is developing. He believes that BRONCH can offer to reduce the need for animal testing to study the effects of pollutants on human health. Min Hyung Ryu is a recipient of a two year studentship from Manitoba Health Research Council to optimize and use bioengineered airways for pre-clinical studies. With the support from BRONCH and MHRC, Min is pursuing his dream of becoming a clinician scientist to improve the therapy and management of lung disease like asthma and COPD.


© 2011 Bioairway Research Offering New Concepts in Health (BRONCH)

funded by the National Sanitarium Association